SIBBM Seminar

Preliminary Programme

Thursday, 4 June

14.30-14.45	Welcome and overview of the meeting
Session I	Signals from the membrane to transcription and DNA repair
14.45-15.30	Key Lecture: Giannino Del Sal (TS) Regulating signalling: the role of phosphorylation dependent prolyl isomerization
15.30-15.55	Marco Bianchi (MI) Sustained oscillations of functional NF-κB encode optimal gene expression programs
15.55-16.20	Coffee Break
16.20-17.30	Poster Session
17.30-17.55	Caterina Missero (NA) Identification of signaling pathways downstream of p63 in embryonic development
17.55-18.20	Michelangelo Cordenonsi (PD) A mutant-p53/Smad complex opposes p63 to empower TGFβ induced metastasis
18.20-18.35	Cecilia Battistelli (RM) Epigenetic mechanisms controlling p57kip2 expression during muscle differentiation
18.35-18.50	Nadine Hornig (NA) A role of mammalian Dicer in transcriptional regulation
18.50-19.05	Cassandra Mostocotto (RM) PARP-1 activity is implicated in the G0-G1 transition of resting cells
19.05-19.20	Stefano Amente (NA) Histone H3 demethylation and its associated oxidative burst trigger initiation of Myc-induced transcription

Friday, 5 June

Session II	Genome stability
09.00-09.45	Key Lecture: Luciano Di Croce (Barcelona) Histone modifications and histone variants in gene silencing, development and tumorigenesis
09.45-10.10	Vincenzo Costanzo (UK/NA) DNA damage response and genome stability: studying the role of ATM and ATR in a cell free system
10.10-10.35	Marco Muzi Falconi (MI) Nucleotide Excision Repair and Exo1 control DNA damage checkpoint activation and control mutation avoidance after UV irradiation
10.35-11.00	Coffee Break
11.00-11.25	Adriana La Volpe (NA) Conserved pathways in genome stability: the model Caenorhabditis elegans
11.25-11.50	Patrizia Lavia (RM) The Ran GTPase network regulates mitotic microtubules dynamics and modulates the efficacy of microtubule-targeting chemotherapeutic drugs
11.50-12.05	Roberta Ferretti (TO) Morgana/chp-1, a new ROCK inhibitor involved in centrosome duplication and tumorigenesis
12.05-12.20	Giovanni Maga (PV) Roles of the human proteins PCNA, RP-A and Fen-1 in avoiding functional redundance between human DNA polymerases β and λ in genomic stability safeguarding
12.20-12.35	Silvia Onesti (TS) Learning to unwind: structural studies of the replicative MCM helicase
12.35-12.50	Nicola Silva (NA) Shedding new light on the function of C. elegans gene msh-4
12.50-13.45	Lunch at the Campus Cafeteria
13.45-14.30	Free time for scientific discussion
Session III	Stem cells and reprogramming
14.30-15.15	Key Lecture: Giulio Cossu (MI) Mesoangioblasts for the cell therapy of muscular dystrophy
15.15-15.40	Salvatore Oliviero (SI) Role of MYC in gene regulation and cell reprogramming
15.40-16.05	Maria Pia Cosma (NA) Molecular mechanisms controlling Wnt/beta-catenin dependent somatic cell reprogramming
16.05-16.30	Vania Broccoli (MI) New strategies for genetic reprogramming and generation of patient-specific iPS cell lines
16.30-16.55	Coffee Break
16.55-18.00	Poster Session
18.00-18.25	Giuseppe Testa (MI) Histone (de)methylation in lineage commitment
18.25-18.50	Fulvio Mavilio (MO) Retroviruses and the human genome: a system biology approach
18.50-19.05	Daniela Galli (PV) In vitro adhesion and bone differentiation of human Mesenchymal Stem Cells (hMSCs) and human Dental Pulp Stem Cells (hDPSCs) on positively charged surfaces
19.05-19.20	Cristina D'Aniello (NA) G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to redirect the neural fate and specify embryonic stem cells toward the cardiac lineage
19.20-19.35	Valentina Bouché (NA) Isolation of Neuronal Stem Cells from Multiple Sulfatase Deficiency as a model to study neurodegeneration in lysosomal storage diseases
19.35-19.50	Luigi Aloia (NA) DiM-1: a new player involved in mouse Embryonic Stem cell differentiation
20.30	Social dinner

Saturday, 6 June

Session IV	Gene networks: new approaches to the analysis of complex systems
09.00-09.45	Key Lecture: Gianni Cesareni (RM) Domain interaction networks and inference of disease genes
09.45-10.10	Diego Di Bernardo (NA) Gene networks and human diseases: tackling complexity with the help of computational biology
10.10-10.35	Paolo Provero (TO) Conserved coexpression networks: a tool for functional genomics and disease gene identification
10.35-11.00	Coffee Break
11.00-11.25	Andrea Ciliberto (MI) A negative feedback loop controls sequestration and release of Cdc14 at the end of mitosis
11.25-11.40	Ugo Ala (TO) Tissue-specific human-mouse conserved co-expression networks for prediction of mammalian genes functional properties
11.40-11.55	Rossella De Cegli (NA) Genome-wide high confidence characterization of differentially expressed genes in mouse embryonic stem cells
11.55-12.10	Francesca Orso (TO) Analysis of the regulatory regions of AP-2α-modulated genes
12.10-13.15	Chiara D'Onofrio "Giovani" Award
13.15	Final remarks